info@caddexindia.com 9015777407
Caddex India Logo
Blog Details

Cleanroom HVAC Design (ISO 14644): Air Changes, HEPA Filtration & Differential Pressures

September 08, 2026 - BY Admin

Cleanroom HVAC Design (ISO 14644): Air Changes, HEPA Filtration & Differential Pressures

Controlling Airborne Particulate Contamination in Pharmaceutical Facilities

Manufacturing semiconductor chips and sterile vaccines requires indoor environments with virtually zero airborne dust particles, governed by international ISO 14644 standards.

Key Cleanroom HVAC Engineering Parameters

Cleanroom design relies on high airflow volumes and strict air pressure cascades.

  • Air Change Rates (ACPH): Delivering 30 to 60+ air changes per hour to flush out airborne particulates.
  • Differential Pressure Cascades: Positive pressure prevents outside dust ingress; negative pressure contains hazardous bio-agents.
  • HEPA/ULPA Filtration: Terminal ceiling filter modules capturing 99.97% of airborne particles down to 0.3 microns.

Learn pharmaceutical and hospital HVAC design in our Cleanroom HVAC Program.

Caddex Logo

Become a Certified Caddex Professional

Enhance your skills with our industry-recognized certification program.

WhatsApp

WhatsApp Enquiry

Knowledge Base

Find answers to various topics in our comprehensive knowledge base.

Categories

Archives

Call Us